Principal Scientist Non-clinical

Principal Scientist Non-clinical

Biotechnology Clinical Life Sciences Pharmaceuticals

Location Slough

Salary 45,000 - 70,000

Contract Permanent

Reference TKpkpd

Date Posted


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Principal Scientist – Non-Clinical

An exciting opportunity has arisen for an experienced non-clinical DMPK scientist to join a global pharmaceutical company on a permanent basis. On offer there is either a Principal Scientist or an Associate Director level, suiting an individual with extensive pharmacokinetics and pharmacology experience.

The main aim of this position is driving the quantitative integrated strategy of pharmacokinetics and pharmacology, together with DMPK activities throughout the entirety of the lifetime of projects, from target identification through to life cycle management.

Main Responsibilities

  • Develop and drive the nonclinical PKPD strategy for projects. Communicate this effectively ensuring implementation in projects.
  • Ensure translation from in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients
  • Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build a thorough knowledge of drug pharmacology and PKPD, leading to quantitative translation to the clinic
  • Build PKPD models to allow hypothesis testing and inform decision-making.
  • Provide scientific and technical input, expertise and leadership to Non-clinical PKPD group, project teams, and Development Sciences (Dev Sci)
  • Work within collaborations with external partners, academic institutions, CROs and consultants as required.
  • Maintain an awareness of new / emerging techniques and tools relevant to the field.
  • Represent the interests of Dev Sci internally and externally in matters relevant to mechanistic PKPD and contribute to enhancing the scientific reputation of Non-Clinical PKPD and Development science
  • As required, contribute to Due Diligence of external project, product and technology opportunities.
  • Provide required support and input into regulatory study protocols, reports and summaries, and regulatory submission documents.

Desired Skills and Experience 

Ideally candidates will be educated to PhD level (or equivalent) in relevant discipline (pharmacology, bioengineering, pharmacokinetics, pharmacodynamics, or relevant scientific discipline). The successful candidate will also possess:

  • Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms
  • Expertise and proven application of PKPD methods and concepts in support of drug discovery and development; systems modelling experience would be advantageous
  • Demonstrated experience in developing and executing effective nonclinical PKPD strategies from early discovery through to clinic
  • Innovative, self-motivated, team-oriented scientist with good written and verbal communication skills, able to handle several projects at any given time, to work successfully in teams and to communicate clearly to a variety of audiences.
  • Demonstrated leadership skills in a matrix environment, capable of working effectively in teams and influencing relevant stakeholders
  • Experience working within a matrix environment with a wide range of internal stakeholders including Non-Clinical Safety, Bioanalysis, Clinical Pharmacology and Translational Medicine.
  • Record of publications and other external scientific contributions relevant to PKPD
  • Experience in using modelling and simulation packages such as Phoenix, Berkeley Madonna, Monolix, R, etc

If this sounds like the opportunity for you, apply with your CV now, and feel free to contact Tom Kirkpatrick at CY Partners for more information.

Principal Scientist Non-clinical

Biotechnology Clinical Life Sciences Pharmaceuticals

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